Researchers from the Coon Group recently contributed proteomic and targeted coenzyme Q intermediate quantification to an interdisciplinary study on the structure role of the COQ9 protein in endogenous coenzyme Q synthesis in the mitochondria. The study was led by the Pagliarini Research Group in the department of biochemistry and included crystallography, differential scanning fluorimetry, cell-free protein expression and other techniques aside from LC/MS analysis.
Together with the Stahl Research Group (UW-Madison), we recently published advances in the depolymerization of lignin to provide valuable aromatics. Lignin is a heterogeneous aromatic polymer that gives rigidity to land plants and accounts for almost 30% of all organic carbon on Earth. Lignin is a side product of paper manufacture and bioethanol production and currently vast amounts are burned as waste. Our methods could make industrial-scale depolymerization an ecomomical and environmentally friendly alternative.